Mus musculus Gene: Adamts14
Summary
InnateDB Gene IDBG-155672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adamts14
Gene Name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000059901
Encoded Proteins
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138316:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:61197112-61273438
Strand Reverse strand
Band B4
Transcripts
ENSMUST00000092486 ENSMUSP00000090143
ENSMUST00000120336 ENSMUSP00000112723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007229 integrin-mediated signaling pathway
GO:0030199 collagen fibril organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Collagen biosynthesis and modifying enzymes pathway
Post-translational protein modification pathway
Extracellular matrix organization pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PX39 Q3UV61
UniProt Splice Variant
Entrez Gene 237360
UniGene Mm.333252
RefSeq NM_001081127 XM_006513618
OMIM
CCDS CCDS35915
HPRD
IMGT
MGI ID MGI:2179942
MGI Symbol Adamts14
EMBL AC123530 AC151895 AK137573
GenPept BAE23412
RNA Seq Atlas 237360