InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6ap1

Summary

InnateDB Gene

IDBG-155785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6ap1

Gene Name

ATPase, H+ transporting, lysosomal accessory protein 1

Synonyms

16A; AC45; AI316502; Atp6ip1; Atp6s1; AW108110; C7-1; CF2; mFLJ00383; VATPS1; XAP-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019087

Encoded Proteins

IDBP-155787

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-252326

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-533911

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-537211

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-537743

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-532002

ATPase, H+ transporting, lysosomal accessory protein 1

IDBP-536642

ATPase, H+ transporting, lysosomal accessory protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071553:
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008]
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:74297097-74304721

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000019231	ENSMUSP00000019231
ENSMUST00000114171	ENSMUSP00000109808
ENSMUST00000147900	ENSMUSP00000117006
ENSMUST00000147275	ENSMUSP00000116162
ENSMUST00000135914
ENSMUST00000124797	ENSMUSP00000118722
ENSMUST00000136056	ENSMUSP00000117604
ENSMUST00000144075
ENSMUST00000144506
ENSMUST00000154630	ENSMUSP00000116432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0015991	ATP hydrolysis coupled proton transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045851	pH reduction
GO:0045921	positive regulation of exocytosis
GO:0051656	establishment of organelle localization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005774	vacuolar membrane
GO:0016021	integral component of membrane
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome