Version 5.4
Mus musculus Gene: Cbl
Summary
InnateDB Gene IDBG-155970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbl
Gene Name Casitas B-lineage lymphoma
Synonyms 4732447J05Rik; c-Cbl; cbl; Cbl-2
Species Mus musculus
Ensembl Gene ENSMUSG00000034342
Encoded Proteins
IDBP-155972
Casitas B-lineage lymphoma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21799517
Cbl, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of Nfkb1.
InnateDB Annotation from Orthologs
Summary
PMID 21799517
[Homo sapiens] CBL, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of NFKB1. (Demonstrated in mouse)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110395:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44149262-44234046
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000037644 ENSMUSP00000041902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 203 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 77 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 203 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016600 flotillin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110395
View Gene Order
ENSBTAG00000006817
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_203917
EGFR downregulation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_189085
Disease pathway
REACT_199123
Signaling by constitutively active EGFR pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_230745
Immune System pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_198526
Spry regulation of FGF signaling pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_242976
Signaling by EGFR pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_261687
Signaling by Interleukins pathway
REACT_199118
Interleukin-6 signaling pathway
REACT_229531
Adaptive Immune System pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_198634
Regulation of signaling by CBL pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04012
ErbB signaling pathway pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_27307
Interleukin-6 signaling pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_111080
Spry regulation of FGF signaling pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_22232
Signaling by Interleukins pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04910
Insulin signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
epha_fwdpathway
EPHA forward signaling
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
reelinpathway
Reelin signaling pathway
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
avb3_integrin_pathway
Integrins in angiogenesis
erbb1_internalization_pathway
Internalization of ErbB1
epopathway
EPO signaling pathway
fgf_pathway
FGF signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
il4_2pathway
IL4-mediated signaling events
cdc42_pathway
CDC42 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
epha2_fwdpathway
EPHA2 forward signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
vegfr1_pathway
VEGFR1 specific signals
pdgfrbpathway
PDGFR-beta signaling pathway
insulin_pathway
Insulin Pathway
ifngpathway
IFN-gamma pathway
notch_pathway
Notch signaling pathway
Cross-References
SwissProt P22682
TrEMBL
UniProt Splice Variant
Entrez Gene 12402
UniGene Mm.266871 Mm.401014 Mm.416155
RefSeq NM_007619 XM_006509964
OMIM
CCDS CCDS40598
HPRD
IMGT
MGI ID MGI:88279
MGI Symbol Cbl
EMBL AK028730 AK153915 BC125285 X57111
GenPept AAI25286 BAC26087 BAE32253 CAA40394
RNA Seq Atlas 12402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca