Version 5.4
Mus musculus Gene: Cd1d2
Summary
InnateDB Gene IDBG-156647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd1d2
Gene Name CD1d2 antigen
Synonyms CD1.2; Cd1b; Ly-38
Species Mus musculus
Ensembl Gene ENSMUSG00000041750
Encoded Proteins
IDBP-156649
CD1d2 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. [provided by RefSeq, Jan 2013]
This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. Alternatively splice transcript variants encoding different isoforms have been found in non-C57BL/6 strains. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:86986586-86989533
Strand Forward strand
Band F1
Transcripts
ENSMUST00000041920 ENSMUSP00000039583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030881 beta-2-microglobulin binding
GO:0030883 endogenous lipid antigen binding
GO:0030884 exogenous lipid antigen binding
GO:0071723 lipopeptide binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0006955 immune response
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045404 positive regulation of interleukin-4 biosynthetic process
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0051135 positive regulation of NK T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04640
Hematopoietic cell lineage pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QLX1
UniProt Splice Variant
Entrez Gene 12480
UniGene Mm.389465
RefSeq NM_007640
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:107675
MGI Symbol Cd1d2
EMBL AC132346
GenPept
RNA Seq Atlas 12480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca