Version 5.4
Mus musculus Gene: Pnp
Summary
InnateDB Gene IDBG-156690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnp
Gene Name purine-nucleoside phosphorylase
Synonyms AL024301; AU015798; Np; Np-1; Np-2; Pnp1
Species Mus musculus
Ensembl Gene ENSMUSG00000021871
Encoded Proteins
IDBP-156694
purine-nucleoside phosphorylase
IDBP-717569
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50944302-50965237
Strand Forward strand
Band C1
Transcripts
ENSMUST00000048615 ENSMUSP00000043926
ENSMUST00000178092 ENSMUSP00000136557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0006139 nucleobase-containing compound metabolic process
GO:0006148 inosine catabolic process
GO:0006149 deoxyinosine catabolic process
GO:0006161 deoxyguanosine catabolic process
GO:0006183 GTP biosynthetic process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0009116 nucleoside metabolic process
GO:0010332 response to gamma radiation
GO:0034418 urate biosynthetic process
GO:0042102 positive regulation of T cell proliferation
GO:0042278 purine nucleoside metabolic process
GO:0045579 positive regulation of B cell differentiation
GO:0045739 positive regulation of DNA repair
GO:0046070 dGTP metabolic process
GO:0046115 guanosine catabolic process
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0070233 negative regulation of T cell apoptotic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu00760
Nicotinate and nicotinamide metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q543K9
UniProt Splice Variant
Entrez Gene 18950
UniGene Mm.17932
RefSeq NM_013632
OMIM
CCDS CCDS27029
HPRD
IMGT
MGI ID MGI:97365
MGI Symbol Pnp
EMBL AC136376 AK049817 AK153451 CT010254
GenPept BAC33932 BAE32005 CAJ18462
RNA Seq Atlas 18950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca