InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acox3

Summary

InnateDB Gene

IDBG-157027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acox3

Gene Name

acyl-Coenzyme A oxidase 3, pristanoyl

Synonyms

BI685180; EST-s59; PCOX

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029098

Encoded Proteins

IDBP-157029

acyl-Coenzyme A oxidase 3, pristanoyl

IDBP-157031

acyl-Coenzyme A oxidase 3, pristanoyl

IDBP-252168

acyl-Coenzyme A oxidase 3, pristanoyl

IDBP-252170

acyl-Coenzyme A oxidase 3, pristanoyl

IDBP-538033

acyl-Coenzyme A oxidase 3, pristanoyl

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087008:
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:35583040-35613801

Strand

Forward strand

Band

Transcripts

ENSMUST00000068947	ENSMUSP00000063412
ENSMUST00000068563	ENSMUSP00000067178
ENSMUST00000114238	ENSMUSP00000109876
ENSMUST00000114237	ENSMUSP00000109875
ENSMUST00000156125	ENSMUSP00000119216
ENSMUST00000127641
ENSMUST00000154796

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0016402	pristanoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0055114	oxidation-reduction process