InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hk1

Summary

InnateDB Gene

IDBG-157046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hk1

Gene Name

hexokinase 1

Synonyms

BB404130; dea; Hk-1; Hk1-s; mHk1-s

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037012

Encoded Proteins

IDBP-157048

hexokinase 1

IDBP-157050

hexokinase 1

IDBP-274612

hexokinase 1

IDBP-537221

hexokinase 1

IDBP-533347

hexokinase 1

IDBP-533869

hexokinase 1

IDBP-533089

hexokinase 1

IDBP-537677

hexokinase 1

IDBP-534567

hexokinase 1

IDBP-540721

hexokinase 1

IDBP-533088

hexokinase 1

IDBP-535489

hexokinase 1

IDBP-539620

hexokinase 1

IDBP-533501

hexokinase 1

IDBP-536535

hexokinase 1

IDBP-541152

hexokinase 1

IDBP-535383

hexokinase 1

IDBP-532695

hexokinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156515:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:62268855-62379908

Strand

Reverse strand

Band

Transcripts

ENSMUST00000072357	ENSMUSP00000072195
ENSMUST00000099691	ENSMUSP00000097282
ENSMUST00000116238	ENSMUSP00000111946
ENSMUST00000130422	ENSMUSP00000118601
ENSMUST00000161160
ENSMUST00000152761	ENSMUSP00000117752
ENSMUST00000139228	ENSMUSP00000118166
ENSMUST00000143179	ENSMUSP00000120151
ENSMUST00000142527
ENSMUST00000143236	ENSMUSP00000115990
ENSMUST00000133429	ENSMUSP00000123375
ENSMUST00000132926	ENSMUSP00000115218
ENSMUST00000134877	ENSMUSP00000121487
ENSMUST00000135317	ENSMUSP00000115426
ENSMUST00000130091	ENSMUSP00000122791
ENSMUST00000134447	ENSMUSP00000122717
ENSMUST00000136548	ENSMUSP00000122479
ENSMUST00000154489	ENSMUSP00000118576
ENSMUST00000140383	ENSMUSP00000114586
ENSMUST00000149534	ENSMUSP00000119812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0061621	canonical glycolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0005929	cilium
GO:0045121	membrane raft
GO:0097228	sperm principal piece