InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ncs1

Summary

InnateDB Gene

IDBG-157707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncs1

Gene Name

neuronal calcium sensor 1

Synonyms

9430075O15Rik; A730032G13Rik; AI836659; Freq; Mfreq; NCS-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062661

Encoded Proteins

IDBP-157709

neuronal calcium sensor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107130:
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:31245823-31295989

Strand

Forward strand

Band

Transcripts

ENSMUST00000000199	ENSMUSP00000000199
ENSMUST00000150670

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0010975	regulation of neuron projection development
GO:0045921	positive regulation of exocytosis
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050806	positive regulation of synaptic transmission
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031045	dense core granule
GO:0031410	cytoplasmic vesicle
GO:0032580	Golgi cisterna membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107130

View Gene Order

ENSBTAG00000008726

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8BNY6

TrEMBL

UniProt Splice Variant

Entrez Gene

14299

UniGene

Mm.249318 Mm.408906 Mm.409125 Mm.487857

RefSeq

NM_019681

OMIM

CCDS

CCDS15896

HPRD

IMGT

MGI ID

MGI:109166

MGI Symbol

Ncs1

EMBL

AF020184 AK079136 AL732572 BC059825

GenPept

AAD01642 AAH59825 BAC37557 CAM21076

RNA Seq Atlas

14299