Version 5.4
Mus musculus Gene: Cxxc1
Summary
InnateDB Gene IDBG-157967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxxc1
Gene Name CXXC finger 1 (PHD domain)
Synonyms 2410002I16Rik; 5830420C16Rik; AI426635; Cfp1; Cgbp; PHF18
Species Mus musculus
Ensembl Gene ENSMUSG00000024560
Encoded Proteins
IDBP-157969
CXXC finger 1 (PHD domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154832:
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:74216131-74221491
Strand Forward strand
Band E2
Transcripts
ENSMUST00000025444 ENSMUSP00000025444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0045322 unmethylated CpG binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154832
View Gene Order
ENSBTAG00000021884
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_218371
IRE1alpha activates chaperones pathway
REACT_213782
Metabolism of proteins pathway
REACT_211201
XBP1(S) activates chaperone genes pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.17537 Mm.454479
RefSeq NM_028868 XM_006526302
OMIM
CCDS CCDS50320
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca