InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpc

Summary

InnateDB Gene

IDBG-158143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpc

Gene Name

heterogeneous nuclear ribonucleoprotein C

Synonyms

AL022939; D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2; Hnrpc; Hnrpc1; Hnrpc2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060373

Encoded Proteins

IDBP-257749

heterogeneous nuclear ribonucleoprotein C

IDBP-620141

heterogeneous nuclear ribonucleoprotein C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092199:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:52073380-52104028

Strand

Reverse strand

Band

Transcripts

ENSMUST00000111610	ENSMUSP00000107237
ENSMUST00000164655	ENSMUSP00000133052

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	121 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0031492	nucleosomal DNA binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043044	ATP-dependent chromatin remodeling
GO:0070935	3'-UTR-mediated mRNA stabilization

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0045120	pronucleus
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome