Version 5.4
Mus musculus Gene: Abl1
Summary
InnateDB Gene IDBG-158216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abl1
Gene Name c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms Abl; AI325092; c-Abl; E430008G22Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026842
Encoded Proteins
IDBP-158218
c-abl oncogene 1, non-receptor tyrosine kinase
IDBP-158220
c-abl oncogene 1, non-receptor tyrosine kinase
IDBP-543037
c-abl oncogene 1, non-receptor tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23325923
ABL1 kinase is required for neutrophil migration.
InnateDB Annotation from Orthologs
Summary
PMID 23325923
[Homo sapiens] ABL1 kinase is required for neutrophil migration.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000097007:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5\' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:31688376-31804227
Strand Forward strand
Band B
Transcripts
ENSMUST00000075759 ENSMUSP00000075167
ENSMUST00000028190 ENSMUSP00000028190
ENSMUST00000146537
ENSMUST00000156736
ENSMUST00000142554
ENSMUST00000123471
ENSMUST00000135233
ENSMUST00000137049
ENSMUST00000124089 ENSMUSP00000117748
ENSMUST00000127714
ENSMUST00000124726
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 268 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 268 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
GO:0019905 syntaxin binding
GO:0030145 manganese ion binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0007155 cell adhesion
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0042770 signal transduction in response to DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051353 positive regulation of oxidoreductase activity
GO:0051726 regulation of cell cycle
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:2001020 regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0031252 cell leading edge
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000097007
View Gene Order
ENSBTAG00000017976
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_224553
Hemostasis pathway
REACT_230745
Immune System pathway
REACT_253473
Myogenesis pathway
REACT_221567
Signaling by Robo receptor pathway
REACT_254504
Role of Abl in Robo-Slit signaling pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_258600
CDO in myogenesis pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04360
Axon guidance pathway
mmu04012
ErbB signaling pathway pathway
mmu04110
Cell cycle pathway
mmu05220
Chronic myeloid leukemia pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05416
Viral myocarditis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_21
RANKL pathway
NetPath_25
FSH pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_21402
CDO in myogenesis pathway
REACT_19230
Role of Abl in Robo-Slit signaling pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_21303
Myogenesis pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_604
Hemostasis pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04360
Axon guidance pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
p53regulationpathway
p53 pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p73pathway
p73 transcription factor network
atm_pathway
ATM pathway
tap63pathway
Validated transcriptional targets of TAp63 isoforms
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
pdgfrbpathway
PDGFR-beta signaling pathway
telomerasepathway
Regulation of Telomerase
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1318
RefSeq NM_001112703 NM_001283045 NM_001283046 NM_001283047 NM_009594
OMIM
CCDS CCDS15901 CCDS50563
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca