Version 5.4
Mus musculus Gene: Tead3
Summary
InnateDB Gene IDBG-158275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tead3
Gene Name TEA domain family member 3
Synonyms DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5
Species Mus musculus
Ensembl Gene ENSMUSG00000002249
Encoded Proteins
IDBP-158277
TEA domain family member 3
IDBP-158279
TEA domain family member 3
IDBP-251010
TEA domain family member 3
IDBP-531496
TEA domain family member 3
IDBP-541874
TEA domain family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28331671-28350805
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000019363 ENSMUSP00000019363
ENSMUST00000080572 ENSMUSP00000079410
ENSMUST00000114799 ENSMUSP00000110447
ENSMUST00000154873 ENSMUSP00000118582
ENSMUST00000156862 ENSMUSP00000115443
ENSMUST00000127212
ENSMUST00000146668
ENSMUST00000151557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0035329 hippo signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000007866
View Gene Order
ENSBTAG00000019495
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6TTJ9 Q8R2N6
UniProt Splice Variant
Entrez Gene 21678
UniGene Mm.450795 Mm.6655
RefSeq NM_001098226 NM_001204156 NM_011566
OMIM
CCDS CCDS28577 CCDS50046
HPRD
IMGT
MGI ID MGI:109241
MGI Symbol Tead3
EMBL BC027383 CT025652
GenPept AAH27383
RNA Seq Atlas 21678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca