Version 5.4
Mus musculus Gene: Hnrnpk
Summary
InnateDB Gene IDBG-158280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpk
Gene Name heterogeneous nuclear ribonucleoprotein K
Synonyms Hnrpk; KBBP; NOVA
Species Mus musculus
Ensembl Gene ENSMUSG00000021546
Encoded Proteins
IDBP-158282
heterogeneous nuclear ribonucleoprotein K
IDBP-274210
heterogeneous nuclear ribonucleoprotein K
IDBP-712722
IDBP-715611
IDBP-712445
IDBP-714885
IDBP-713953
IDBP-713676
IDBP-715364
IDBP-714347
IDBP-712693
IDBP-715160
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:58391142-58403343
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000043269 ENSMUSP00000039269
ENSMUST00000116403 ENSMUSP00000112104
ENSMUST00000175847 ENSMUSP00000134837
ENSMUST00000176269
ENSMUST00000176257
ENSMUST00000176207 ENSMUSP00000135354
ENSMUST00000176558 ENSMUSP00000135623
ENSMUST00000176849 ENSMUSP00000135342
ENSMUST00000176305 ENSMUSP00000135305
ENSMUST00000176359
ENSMUST00000177060 ENSMUSP00000135407
ENSMUST00000175939
ENSMUST00000177497 ENSMUSP00000135833
ENSMUST00000176609
ENSMUST00000177117 ENSMUSP00000135109
ENSMUST00000176888
ENSMUST00000176725
ENSMUST00000176797 ENSMUSP00000135867
ENSMUST00000177019 ENSMUSP00000135647
ENSMUST00000177377
ENSMUST00000177051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 164 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 164 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0002102 podosome
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0019013 viral nucleocapsid
GO:0030054 cell junction
GO:0030529 ribonucleoprotein complex
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165119
View Gene Order
ENSBTAG00000021131
Not yet available
Pathways
NETPATH
REACTOME
REACT_249110
mRNA Splicing pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.142872 Mm.338129 Mm.402529
RefSeq NM_025279 XM_006517101 XM_006517102 XM_006517103 XM_006517104 XM_006517105 XM_006517106 XM_006517107
OMIM
CCDS CCDS49283
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca