Version 5.4
Mus musculus Gene: Wfs1
Summary
InnateDB Gene IDBG-158640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wfs1
Gene Name Wolfram syndrome 1 homolog (human)
Synonyms AI481085; wolframin
Species Mus musculus
Ensembl Gene ENSMUSG00000039474
Encoded Proteins
IDBP-158642
Wolfram syndrome 1 homolog (human)
IDBP-627436
Wolfram syndrome 1 homolog (human)
IDBP-627437
Wolfram syndrome 1 homolog (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109501:
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:36966104-36988982
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000043964 ENSMUSP00000048053
ENSMUST00000166339 ENSMUSP00000132404
ENSMUST00000167937 ENSMUSP00000125779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005516 calmodulin binding
GO:0031625 ubiquitin protein ligase binding
GO:0033613 activating transcription factor binding
GO:0048306 calcium-dependent protein binding
GO:0051117 ATPase binding
Biological Process
GO:0001822 kidney development
GO:0003091 renal water homeostasis
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031398 positive regulation of protein ubiquitination
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0034976 response to endoplasmic reticulum stress
GO:0042048 olfactory behavior
GO:0042593 glucose homeostasis
GO:0043069 negative regulation of programmed cell death
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045862 positive regulation of proteolysis
GO:0045927 positive regulation of growth
GO:0050821 protein stabilization
GO:0050877 neurological system process
GO:0051247 positive regulation of protein metabolic process
GO:0051726 regulation of cell cycle
GO:0051928 positive regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0070845 polyubiquitinated misfolded protein transport
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109501
View Gene Order
ENSBTAG00000046671
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P56695
TrEMBL Q3TDI2
UniProt Splice Variant
Entrez Gene 22393
UniGene Mm.20916 Mm.470263
RefSeq NM_011716
OMIM
CCDS CCDS19245
HPRD
IMGT
MGI ID MGI:1328355
MGI Symbol Wfs1
EMBL AF084482 AJ011971 AK170180 CH466524
GenPept AAC64944 BAE41619 CAA09892 EDL37519
RNA Seq Atlas 22393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca