Version 5.4
Mus musculus Gene: Ntrk1
Summary
InnateDB Gene IDBG-158646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ntrk1
Gene Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms C80751; Tkr; trk; TrkA
Species Mus musculus
Ensembl Gene ENSMUSG00000028072
Encoded Proteins
IDBP-158648
neurotrophic tyrosine kinase, receptor, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198400:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87778244-87795162
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029712 ENSMUSP00000029712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005166 neurotrophin p75 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0010465 nerve growth factor receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0046875 ephrin receptor binding
GO:0048406 nerve growth factor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007568 aging
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0010623 developmental programmed cell death
GO:0010976 positive regulation of neuron projection development
GO:0014823 response to activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019233 sensory perception of pain
GO:0021553 olfactory nerve development
GO:0030183 B cell differentiation
GO:0031667 response to nutrient levels
GO:0032320 positive regulation of Ras GTPase activity
GO:0035094 response to nicotine
GO:0038180 nerve growth factor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0043068 positive regulation of programmed cell death
GO:0043524 negative regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0045766 positive regulation of angiogenesis
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048485 sympathetic nervous system development
GO:0048678 response to axon injury
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051599 response to hydrostatic pressure
GO:0051602 response to electrical stimulus
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060009 Sertoli cell development
GO:0060385 axonogenesis involved in innervation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071316 cellular response to nicotine
GO:0071363 cellular response to growth factor stimulus
GO:1901215 negative regulation of neuron death
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198400
View Gene Order
ENSBTAG00000003060
Not yet available
Pathways
NETPATH
REACTOME
REACT_205300
PI3K/AKT activation pathway
REACT_213333
TRKA activation by NGF pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_239722
Signalling to RAS pathway
REACT_262560
Frs2-mediated activation pathway
REACT_212952
Signalling to STAT3 pathway
REACT_231290
Signalling to ERKs pathway
REACT_248921
Signalling by NGF pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_234035
ARMS-mediated activation pathway
REACT_188257
Signal Transduction pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_209347
NGF-independant TRKA activation pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_217410
Activation of TRKA receptors pathway
KEGG
mmu05216
Thyroid cancer pathway
mmu04010
MAPK signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12464
PI3K/AKT activation pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_11046
NGF-independant TRKA activation pathway
REACT_11060
TRKA activation by NGF pathway
REACT_12049
Signalling to STAT3 pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_11064
Activation of TRKA receptors pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p75ntrpathway
p75(NTR)-mediated signaling
p73pathway
p73 transcription factor network
Cross-References
SwissProt Q3UFB7
TrEMBL
UniProt Splice Variant
Entrez Gene 18211
UniGene Mm.80682
RefSeq NM_001033124 XM_006501124
OMIM
CCDS CCDS50947
HPRD
IMGT
MGI ID MGI:97383
MGI Symbol Ntrk1
EMBL AK081588 AK148691
GenPept BAE28644
RNA Seq Atlas 18211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca