Version 5.4
Mus musculus Gene: Hdgf
Summary
InnateDB Gene IDBG-158996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdgf
Gene Name hepatoma-derived growth factor
Synonyms AI118077; D3Ertd299e
Species Mus musculus
Ensembl Gene ENSMUSG00000004897
Encoded Proteins
IDBP-158998
hepatoma-derived growth factor
IDBP-534440
hepatoma-derived growth factor
IDBP-537671
hepatoma-derived growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143321:
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87906321-87916132
Strand Forward strand
Band F1
Transcripts
ENSMUST00000005017 ENSMUSP00000005017
ENSMUST00000159492 ENSMUSP00000124803
ENSMUST00000162631 ENSMUSP00000123832
ENSMUST00000161616
ENSMUST00000160198
ENSMUST00000160312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 153 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 153 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0009987 cellular process
GO:0034504 protein localization to nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143321
View Gene Order
ENSBTAG00000039793
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E0CXA0
UniProt Splice Variant
Entrez Gene 15191
UniGene Mm.292208 Mm.473178
RefSeq NM_008231
OMIM
CCDS CCDS17457
HPRD
IMGT
MGI ID MGI:1194494
MGI Symbol Hdgf
EMBL AC158233
GenPept
RNA Seq Atlas 15191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca