Version 5.4
Mus musculus Gene: Pole4
Summary
InnateDB Gene IDBG-159021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pole4
Gene Name polymerase (DNA-directed), epsilon 4 (p12 subunit)
Synonyms 2400007P05Rik; 5830430F06Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000030042
Encoded Proteins
IDBP-159023
polymerase (DNA-directed), epsilon 4 (p12 subunit)
IDBP-536249
polymerase (DNA-directed), epsilon 4 (p12 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115350:
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:82618992-82705365
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000095786 ENSMUSP00000093462
ENSMUST00000161309
ENSMUST00000160281 ENSMUSP00000124357
ENSMUST00000141138
ENSMUST00000140281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005622 intracellular
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0008622 epsilon DNA polymerase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115350
View Gene Order
ENSBTAG00000017189
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
mmu03420
Nucleotide excision repair pathway
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E0CYA9
UniProt Splice Variant
Entrez Gene 66979
UniGene Mm.195753 Mm.473913
RefSeq NM_025882
OMIM
CCDS CCDS39524
HPRD
IMGT
MGI ID MGI:1914229
MGI Symbol Pole4
EMBL AC116811 AC159655
GenPept
RNA Seq Atlas 66979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca