Version 5.4
Mus musculus Gene: Crabp2
Summary
InnateDB Gene IDBG-159183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crabp2
Gene Name cellular retinoic acid binding protein II
Synonyms AI893628; Crabp-2; CrabpII
Species Mus musculus
Ensembl Gene ENSMUSG00000004885
Encoded Proteins
IDBP-159185
cellular retinoic acid binding protein II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143320:
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87948666-87953376
Strand Forward strand
Band F1
Transcripts
ENSMUST00000005019 ENSMUSP00000005019
ENSMUST00000163040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005215 transporter activity
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0002138 retinoic acid biosynthetic process
GO:0006810 transport
GO:0035115 embryonic forelimb morphogenesis
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143320
View Gene Order
ENSBTAG00000005716
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_226284
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_253080
Pyruvate metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_257268
Import of palmitoyl-CoA into the mitochondrial matrix pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12528
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_2071
Pyruvate metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4757
RefSeq NM_007759
OMIM
CCDS CCDS17460
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca