Version 5.4
Mus musculus Gene: Nes
Summary
InnateDB Gene IDBG-159220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nes
Gene Name nestin
Synonyms AA166324; C78523; ESTM46
Species Mus musculus
Ensembl Gene ENSMUSG00000004891
Encoded Proteins
IDBP-159222
nestin
IDBP-532139
nestin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132688:
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87971078-87980451
Strand Forward strand
Band F1
Transcripts
ENSMUST00000090973 ENSMUSP00000088493
ENSMUST00000159830
ENSMUST00000160694 ENSMUSP00000125571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0019215 intermediate filament binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007399 nervous system development
GO:0007420 brain development
GO:0030844 positive regulation of intermediate filament depolymerization
GO:0031076 embryonic camera-type eye development
GO:0032091 negative regulation of protein binding
GO:0043086 negative regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0048858 cell projection morphogenesis
GO:0072089 stem cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132688
View Gene Order
ENSBTAG00000015794
Not yet available
Cross-References
SwissProt Q6P5H2
TrEMBL
UniProt Splice Variant
Entrez Gene 18008
UniGene Mm.331129
RefSeq NM_016701
OMIM
CCDS CCDS17461
HPRD
IMGT
MGI ID MGI:101784
MGI Symbol Nes
EMBL AF076623 AK009706 AK075690 BC060693 BC062893 EF101559 S78708
GenPept AAF04456 AAH60693 AAH62893 AAP32014 ABK96808 BAB26451 BAC35892
RNA Seq Atlas 18008

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca