Version 5.4
Mus musculus Gene: Esrrb
Summary
InnateDB Gene IDBG-159268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Esrrb
Gene Name estrogen related receptor, beta
Synonyms Err2; Errb; Estrrb; Nr3b2
Species Mus musculus
Ensembl Gene ENSMUSG00000021255
Encoded Proteins
IDBP-159270
estrogen related receptor, beta
IDBP-260759
estrogen related receptor, beta
IDBP-260761
estrogen related receptor, beta
IDBP-274212
estrogen related receptor, beta
IDBP-621338
estrogen related receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119715:
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:86361117-86521628
Strand Forward strand
Band D2
Transcripts
ENSMUST00000021680 ENSMUSP00000021680
ENSMUST00000110204 ENSMUSP00000105833
ENSMUST00000110203 ENSMUSP00000105832
ENSMUST00000116402 ENSMUSP00000112103
ENSMUST00000136464
ENSMUST00000167891 ENSMUSP00000131335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 96 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001831 trophectodermal cellular morphogenesis
GO:0001834 trophectodermal cell proliferation
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0019827 stem cell maintenance
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119715
View Gene Order
ENSBTAG00000012285
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QKA2 Q80VS1
UniProt Splice Variant
Entrez Gene 26380
UniGene Mm.235550 Mm.418593
RefSeq NM_001159500 XM_006515881 XM_006515882 NM_011934
OMIM
CCDS CCDS49117 CCDS26066
HPRD
IMGT
MGI ID MGI:1346832
MGI Symbol Esrrb
EMBL AC126685 AC132189 AK052256 BC044858 BC132595 BC132597 S82458 X89594
GenPept AAB37687 AAH44858 AAI32596 AAI32598 BAC34898 CAA61755
RNA Seq Atlas 26380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca