Version 5.4
Homo sapiens Gene: C1R
Summary
InnateDB Gene IDBG-15930.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1R
Gene Name complement component 1, r subcomponent
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159403
Encoded Proteins
IDBP-594307
complement component 1, r subcomponent
IDBP-599359
complement component 1, r subcomponent
IDBP-588908
complement component 1, r subcomponent
IDBP-590639
complement component 1, r subcomponent
IDBP-592523
complement component 1, r subcomponent
IDBP-590534
complement component 1, r subcomponent
IDBP-592146
complement component 1, r subcomponent
IDBP-603372
complement component 1, r subcomponent
IDBP-593940
complement component 1, r subcomponent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11445589
C1R is the protease that mediates activation of the classical complement C1 complex and this catalytic property is mediated by C1R C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:7080209-7092607
Strand Reverse strand
Band p13.31
Transcripts
ENST00000540394
ENST00000536053 ENSP00000444271
ENST00000535233 ENSP00000438636
ENST00000543362 ENSP00000446356
ENST00000540610 ENSP00000439223
ENST00000543835 ENSP00000445285
ENST00000541042 ENSP00000441601
ENST00000543851
ENST00000540242 ENSP00000442946
ENST00000538050 ENSP00000444009
ENST00000545466
ENST00000536092
ENST00000542285 ENSP00000438615
ENST00000602298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000055172
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05150
Staphylococcus aureus infection pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5GWL0 F5H1N6 F5H3N3
UniProt Splice Variant
Entrez Gene 715
UniGene Hs.600829
RefSeq NM_001733
HUGO HGNC:1246
OMIM 613785
CCDS
HPRD 01954
IMGT
EMBL AC154092 AC233309
GenPept
RNA Seq Atlas 715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca