Version 5.4
Mus musculus Gene: Lpl
Summary
InnateDB Gene IDBG-159560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpl
Gene Name lipoprotein lipase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000015568
Encoded Proteins
IDBP-159564
lipoprotein lipase
IDBP-619753
lipoprotein lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175445:
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:68880491-68907448
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000015712 ENSMUSP00000015712
ENSMUST00000101463
ENSMUST00000168401 ENSMUSP00000132259
ENSMUST00000169749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004465 lipoprotein lipase activity
GO:0004806 triglyceride lipase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0017129 triglyceride binding
GO:0034185 apolipoprotein binding
Biological Process
GO:0006629 lipid metabolic process
GO:0009409 response to cold
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0010890 positive regulation of sequestering of triglyceride
GO:0016042 lipid catabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0042493 response to drug
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0031225 anchored component of membrane
GO:0034361 very-low-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175445
View Gene Order
ENSBTAG00000012855
Not yet available
Pathways
NETPATH
REACTOME
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_189085
Disease pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_216017
Chylomicron-mediated lipid transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_188576
Developmental Biology pathway
REACT_188260
Visual phototransduction pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
mmu05010
Alzheimer's disease pathway
mmu03320
PPAR signaling pathway pathway
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_206940
Chylomicron-mediated lipid transport pathway
REACT_204227
Retinoid metabolism and transport pathway
REACT_212432
Lipoprotein metabolism pathway
REACT_223698
Visual phototransduction pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207087
Disease pathway
REACT_220844
Developmental Biology pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa03320
PPAR signaling pathway pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P11152
TrEMBL Q3UAX2
UniProt Splice Variant
Entrez Gene 16956
UniGene Mm.1514 Mm.401817 Mm.418638 Mm.470568
RefSeq NM_008509 XM_006509563
OMIM
CCDS CCDS40357
HPRD
IMGT
MGI ID MGI:96820
MGI Symbol Lpl
EMBL AK002645 AK017272 AK045064 AK086023 AK150355 AK150375 AK150457 AK150488 AK150505 AK150593 AK150672 AK151006 AK151038 AK151093 AK151105 AK151195 AK151369 AK151434 AK151521 AK151540 AK151563 AK151630 AK151679 AK151727 AK151772 AK151801 AK151828 AK151866 AK151870 AK151872 AK151893 AK152014 AK152035 AK152049 AK152053 AK152079 AK152350 AK152657 AK153148 AK153242 AK153425 AK159268 AK170486 BC003305 J03302 M60838 M60839 M60840 M60842 M60843 M60844 M60845 M60846 M60847 M63335 M65258
GenPept AAA39440 AAA39441 AAA39442 AAC04464 AAH03305 BAB22256 BAC32204 BAC39594 BAE29491 BAE29507 BAE29577 BAE29604 BAE29618 BAE29686 BAE29754 BAE30029 BAE30055 BAE30105 BAE30115 BAE30192 BAE30343 BAE30397 BAE30470 BAE30486 BAE30505 BAE30564 BAE30604 BAE30645 BAE30678 BAE30701 BAE30723 BAE30754 BAE30758 BAE30760 BAE30777 BAE30876 BAE30894 BAE30905 BAE30909 BAE30930 BAE31144 BAE31394 BAE31758 BAE31834 BAE31984 BAE34947 BAE41828
RNA Seq Atlas 16956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca