Version 5.4
Mus musculus Gene: Cyth4
Summary
InnateDB Gene IDBG-159592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyth4
Gene Name cytohesin 4
Synonyms 2510004M07Rik; 5830469K17Rik; AI467541; mFLJ00017; Pscd4
Species Mus musculus
Ensembl Gene ENSMUSG00000018008
Encoded Proteins
IDBP-159594
cytohesin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100055:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78597047-78622019
Strand Forward strand
Band E1
Transcripts
ENSMUST00000043069 ENSMUSP00000042698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0008289 lipid binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100055
View Gene Order
ENSBTAG00000014237
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q80YW0
TrEMBL Q3U0C0 Q571J1
UniProt Splice Variant
Entrez Gene 72318
UniGene
RefSeq NM_028195 XM_006521446
OMIM
CCDS CCDS27620
HPRD
IMGT
MGI ID MGI:2441702
MGI Symbol Cyth4
EMBL AF079972 AK157026 AK220198 BC139054 BC139056 CH466545
GenPept AAD46734 AAI39055 AAI39057 BAD90123 BAE33935 EDL29693
RNA Seq Atlas 72318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca