Version 5.4
Mus musculus Gene: Lipa
Summary
InnateDB Gene IDBG-159667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lipa
Gene Name lysosomal acid lipase A
Synonyms AA960673; Lal; Lip-1; Lip1
Species Mus musculus
Ensembl Gene ENSMUSG00000024781
Encoded Proteins
IDBP-159669
lysosomal acid lipase A
IDBP-704385
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107798:
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34492318-34527474
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000049572 ENSMUSP00000053270
ENSMUST00000178114 ENSMUSP00000136967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004771 sterol esterase activity
GO:0016298 lipase activity
Biological Process
GO:0000902 cell morphogenesis
GO:0001816 cytokine production
GO:0006629 lipid metabolic process
GO:0006954 inflammatory response
GO:0008283 cell proliferation
GO:0016042 lipid catabolic process
GO:0030324 lung development
GO:0048771 tissue remodeling
GO:0048873 homeostasis of number of cells within a tissue
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107798
View Gene Order
ENSBTAG00000003636
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00100
Steroid biosynthesis pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00100
Steroid biosynthesis pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z0M5
TrEMBL
UniProt Splice Variant
Entrez Gene 16889
UniGene Mm.157545 Mm.409827
RefSeq NM_001111100 NM_021460
OMIM
CCDS CCDS29760
HPRD
IMGT
MGI ID MGI:96789
MGI Symbol Lipa
EMBL AK088659 AK149791 AK164007 CH466534 Z31689
GenPept BAC40484 BAE29088 BAE37585 CAA83494 EDL41750
RNA Seq Atlas 16889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca