Mus musculus Gene: Fxyd2 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-159670.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Fxyd2 | ||||||||||||
Gene Name | FXYD domain-containing ion transport regulator 2 | ||||||||||||
Synonyms | Atp1g1 | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000059412 | ||||||||||||
Encoded Proteins |
FXYD domain-containing ion transport regulator 2
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009] This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme\'s activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 9:45403138-45410278 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | A5.2 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Ion channel transport pathway
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
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KEGG |
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Protein digestion and absorption pathway
Carbohydrate digestion and absorption pathway
Salivary secretion pathway
Bile secretion pathway
Proximal tubule bicarbonate reclamation pathway
Pancreatic secretion pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Ion transport by P-type ATPases pathway
Transmembrane transport of small molecules pathway
Ion channel transport pathway
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KEGG |
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
Protein digestion and absorption pathway
Carbohydrate digestion and absorption pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q04646 | ||||||||||||
TrEMBL | Q6ITT1 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 11936 | ||||||||||||
UniGene | |||||||||||||
RefSeq | NM_052823 XM_006509958 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS23134 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | MGI:1195260 | ||||||||||||
MGI Symbol | Fxyd2 | ||||||||||||
EMBL | AK002215 AY035583 AY626244 BC024614 CH466522 X70060 | ||||||||||||
GenPept | AAH24614 AAK62036 AAK62037 AAK62038 AAT45732 BAC24981 CAA49664 EDL25651 | ||||||||||||
RNA Seq Atlas | 11936 | ||||||||||||