Version 5.4
Mus musculus Gene: Ifit3
Summary
InnateDB Gene IDBG-159817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ifit3
Gene Name interferon-induced protein with tetratricopeptide repeats 3
Synonyms Ifi49; P49
Species Mus musculus
Ensembl Gene ENSMUSG00000074896
Encoded Proteins
IDBP-159783
interferon-induced protein with tetratricopeptide repeats 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21813773
Ifit3 triggers host antiviral responses by bridging Tbk1 to Mavs, and Ifit3 plays an important role in the activation of Irf3. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34583531-34588731
Strand Forward strand
Band C1
Transcripts
ENSMUST00000102825 ENSMUSP00000099889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0035457 cellular response to interferon-alpha
GO:0035458 cellular response to interferon-beta
GO:0035634 response to stilbenoid
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010501
OMIM
CCDS CCDS29762
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca