InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gstz1

Summary

InnateDB Gene

IDBG-159928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstz1

Gene Name

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

Synonyms

MAAI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021033

Encoded Proteins

IDBP-159930

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100577:
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:87147707-87164721

Strand

Forward strand

Band

Transcripts

ENSMUST00000063117

ENSMUSP00000053540

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016034	maleylacetoacetate isomerase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006749	glutathione metabolic process
GO:0009072	aromatic amino acid family metabolic process