Version 5.4
Mus musculus Gene: Hba-a1
Summary
InnateDB Gene IDBG-159940.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hba-a1
Gene Name hemoglobin alpha, adult chain 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000069919
Encoded Proteins
IDBP-159944
hemoglobin alpha, adult chain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188536:
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:32283511-32284465
Strand Forward strand
Band A4
Transcripts
ENSMUST00000093209 ENSMUSP00000090897
ENSMUST00000142555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0015671 oxygen transport
Cellular Component
GO:0005833 hemoglobin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188536
View Gene Order
ENSBTAG00000026417
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05144
Malaria pathway
mmu05143
African trypanosomiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_121380
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_121329
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_120969
O2/CO2 exchange in erythrocytes pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111217
Metabolism pathway
REACT_213179
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_227215
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_210959
O2/CO2 exchange in erythrocytes pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_219139
Metabolism pathway
REACT_219679
Scavenging of heme from plasma pathway
KEGG
hsa05144
Malaria pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_008218
OMIM
CCDS CCDS24523
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca