InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mogs

Summary

InnateDB Gene

IDBG-160145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mogs

Gene Name

mannosyl-oligosaccharide glucosidase

Synonyms

1810017N02Rik; AI181835; Gcs1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030036

Encoded Proteins

IDBP-160147

mannosyl-oligosaccharide glucosidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115275:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:83115496-83118898

Strand

Forward strand

Band

Transcripts

ENSMUST00000032114	ENSMUSP00000032114
ENSMUST00000145403

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003824	catalytic activity
GO:0004573	mannosyl-oligosaccharide glucosidase activity

Biological Process

GO:0009311

oligosaccharide metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115275

View Gene Order

ENSBTAG00000001844

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_236283

Post-translational protein modification pathway

REACT_237472

Asparagine N-linked glycosylation pathway

REACT_198618

N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway

KEGG

mmu00510

N-Glycan biosynthesis pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_23878

N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28188 Mm.399664

RefSeq

NM_020619 XM_006506424

OMIM

CCDS

CCDS20273

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas