Mus musculus Gene: Mthfd2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-160765.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Mthfd2 | ||||||||||||||
Gene Name | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | ||||||||||||||
Synonyms | AW558851; NMDMC | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Gene | ENSMUSG00000005667 | ||||||||||||||
Encoded Proteins |
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065911:
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 6:83305691-83317606 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | C3 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME | |||||||||||||||
KEGG |
One carbon pool by folate pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME | |||||||||||||||
KEGG |
One carbon pool by folate pathway
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INOH |
Folate metabolism pathway
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PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Mm.443 | ||||||||||||||
RefSeq | NM_008638 XM_006505697 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS20277 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||