InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc7a7

Summary

InnateDB Gene

IDBG-161063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a7

Gene Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

Synonyms

AI790233; my+lat1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000958

Encoded Proteins

IDBP-161065

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155465:
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:54369444-54409472

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000984

ENSMUSP00000000984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000155465

View Gene Order

ENSBTAG00000014821

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_247550

SLC-mediated transmembrane transport pathway

REACT_251788

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_211508

Basigin interactions pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_230460

Amino acid transport across the plasma membrane pathway

KEGG

mmu04974

Protein digestion and absorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12560

Basigin interactions pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_13796

Amino acid transport across the plasma membrane pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Z1K8

TrEMBL

UniProt Splice Variant

Entrez Gene

20540

UniGene

RefSeq

NM_001253679 NM_001253680 NM_011405 XM_006518745 XM_006518746 XM_006518747 XM_006518748 XM_006518749 XM_006518750 XM_006518751 XM_006518752 XM_006518753 XM_006518754 XM_006518755

OMIM

CCDS

CCDS27087

HPRD

IMGT

MGI ID

MGI:1337120

MGI Symbol

Slc7a7

EMBL

AJ012754 AJ130943 AK150950 AK151718 AK152637 AK170851 BC014709

GenPept

AAH14709 BAE29983 BAE30637 BAE31379 BAE42073 CAA10170 CAA10255

RNA Seq Atlas

20540