Version 5.4
| Mus musculus Gene: Dio2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-161130.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dio2 | ||||||||
| Gene Name | deiodinase, iodothyronine, type II | ||||||||
| Synonyms | 5DII; AI324267; DIOII | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000007682 | ||||||||
| Encoded Proteins |
deiodinase, iodothyronine, type II
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3\',5-triiodothyronine (T3). Knockout studies in mice suggest that this gene may play a role in brown adipose tissue lipogenesis, auditory function, and bone formation. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 12:90724554-90738438 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | D3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Regulation of thyroid hormone activity pathway
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Regulation of thyroid hormone activity pathway
Metabolism pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9Z1Y9 | ||||||||
| TrEMBL | Q9ES98 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 13371 | ||||||||
| UniGene | Mm.21389 Mm.405144 Mm.408815 | ||||||||
| RefSeq | NM_010050 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36514 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1338833 | ||||||||
| MGI Symbol | Dio2 | ||||||||
| EMBL | AF093137 AF096875 AF177196 AH009875 BC125383 BC125385 | ||||||||
| GenPept | AAD11422 AAD53113 AAF00069 AAG23127 AAI25384 AAI25386 | ||||||||
| RNA Seq Atlas | 13371 | ||||||||