Version 5.4
Mus musculus Gene: Apoa1
Summary
InnateDB Gene IDBG-161189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoa1
Gene Name apolipoprotein A-I
Synonyms Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2
Species Mus musculus
Ensembl Gene ENSMUSG00000032083
Encoded Proteins
IDBP-161191
apolipoprotein A-I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22271762
Apoa1 has anti-inflammatory properties in macrophages through the stabilization of ATP-binding cassette transporter A1 (Abca1) and the down-regulation of Tlr4 signalling pathway. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 20519121
[Homo sapiens] APOA1 is a serum apolipoprotein that induces antiatherogenic efflux of macrophage cholesterol and is anti-inflammatory due to its ability to neutralize bacterial lipopolysaccharide (LPS). APOA1 also signals in the macrophage through Toll-like receptor (TLR)2, TLR4, and CD14, utilizing MYD88-dependent and -independent pathways, to activate nuclear factor-kappaB and induce cytokines.
PMID 22271762
[Homo sapiens] APOA1 has anti-inflammatory properties in macrophages through the stabilization of ATP-binding cassette transporter A1 (ABCA1) and the down-regulation of TLR4 signalling pathway.
Entrez Gene
Summary This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:46228580-46230466
Strand Forward strand
Band A5.2
Transcripts
ENSMUST00000034588 ENSMUSP00000034588
ENSMUST00000132155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 13 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005548 phospholipid transporter activity
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
GO:0019899 enzyme binding
GO:0034190 apolipoprotein receptor binding
GO:0034191 apolipoprotein A-I receptor binding
GO:0042802 identical protein binding
GO:0055102 lipase inhibitor activity
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653 high-density lipoprotein particle receptor binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006869 lipid transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873 positive regulation of cholesterol esterification
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0014012 peripheral nervous system axon regeneration
GO:0015914 phospholipid transport
GO:0018158 protein oxidation
GO:0018206 peptidyl-methionine modification
GO:0019915 lipid storage
GO:0030300 regulation of intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030325 adrenal gland development
GO:0031100 organ regeneration
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034380 high-density lipoprotein particle assembly
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0043534 blood vessel endothelial cell migration
GO:0043627 response to estrogen
GO:0043691 reverse cholesterol transport
GO:0045087 innate immune response (InnateDB)
GO:0050713 negative regulation of interleukin-1 beta secretion
GO:0050728 negative regulation of inflammatory response
GO:0050821 protein stabilization
GO:0051345 positive regulation of hydrolase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051347 positive regulation of transferase activity
GO:0055091 phospholipid homeostasis
GO:0060192 negative regulation of lipase activity
GO:0060354 negative regulation of cell adhesion molecule production
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070328 triglyceride homeostasis
GO:0070508 cholesterol import
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0009986 cell surface
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118137
View Gene Order
ENSBTAG00000002258
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_198563
Amyloids pathway
REACT_213857
HDL-mediated lipid transport pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_196575
Scavenging of heme from plasma pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_197984
ABCA transporters in lipid homeostasis pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_216017
Chylomicron-mediated lipid transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188260
Visual phototransduction pathway
REACT_237882
ABC-family proteins mediated transport pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_196592
Scavenging by Class B Receptors pathway
KEGG
mmu03320
PPAR signaling pathway pathway
mmu04975
Fat digestion and absorption pathway
mmu05143
African trypanosomiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_111158
ABCA transporters in lipid homeostasis pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_24968
Retinoid metabolism and transport pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_13621
HDL-mediated lipid transport pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_75925
Amyloids pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_163679
Scavenging by Class B Receptors pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_202252
Platelet degranulation pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_206540
Amyloids pathway
REACT_206940
Chylomicron-mediated lipid transport pathway
REACT_205375
ABC-family proteins mediated transport pathway
REACT_204227
Retinoid metabolism and transport pathway
REACT_226243
ABCA transporters in lipid homeostasis pathway
REACT_212432
Lipoprotein metabolism pathway
REACT_212196
Hemostasis pathway
REACT_223698
Visual phototransduction pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_209041
Scavenging by Class A Receptors pathway
REACT_222480
HDL-mediated lipid transport pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_219679
Scavenging of heme from plasma pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_207087
Disease pathway
REACT_227409
Scavenging by Class B Receptors pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa04975
Fat digestion and absorption pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_009692
OMIM
CCDS CCDS40610
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca