Version 5.4
Mus musculus Gene: Actg2
Summary
InnateDB Gene IDBG-161272.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actg2
Gene Name actin, gamma 2, smooth muscle, enteric
Synonyms Act-4; Act4; ACTA3; SMGA
Species Mus musculus
Ensembl Gene ENSMUSG00000059430
Encoded Proteins
IDBP-161274
actin, gamma 2, smooth muscle, enteric
IDBP-401055
actin, gamma 2, smooth muscle, enteric
IDBP-535447
actin, gamma 2, smooth muscle, enteric
IDBP-539761
actin, gamma 2, smooth muscle, enteric
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163017:
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83512905-83536265
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000075161 ENSMUSP00000074658
ENSMUST00000121731 ENSMUSP00000113552
ENSMUST00000141904 ENSMUSP00000120936
ENSMUST00000124933
ENSMUST00000152029 ENSMUSP00000121577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0071944 cell periphery
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000163017
View Gene Order
Pathways
NETPATH
REACTOME
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.292865
RefSeq NM_009610
OMIM
CCDS CCDS51822
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca