Version 5.4
Mus musculus Gene: Arhgef2
Summary
InnateDB Gene IDBG-161396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef2
Gene Name rho/rac guanine nucleotide exchange factor (GEF) 2
Synonyms AA408978; GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; P40
Species Mus musculus
Ensembl Gene ENSMUSG00000028059
Encoded Proteins
IDBP-161398
rho/rac guanine nucleotide exchange factor (GEF) 2
IDBP-266501
rho/rac guanine nucleotide exchange factor (GEF) 2
IDBP-620712
rho/rac guanine nucleotide exchange factor (GEF) 2
IDBP-717194
IDBP-716232
IDBP-717946
IDBP-715963
IDBP-716893
IDBP-716918
IDBP-717678
IDBP-716587
IDBP-717040
IDBP-715746
IDBP-716349
IDBP-715826
IDBP-715797
IDBP-716839
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116584:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:88607454-88648052
Strand Forward strand
Band F1
Transcripts
ENSMUST00000029694 ENSMUSP00000029694
ENSMUST00000107510 ENSMUSP00000103134
ENSMUST00000170653 ENSMUSP00000127843
ENSMUST00000177498 ENSMUSP00000134840
ENSMUST00000176804 ENSMUSP00000135397
ENSMUST00000177099
ENSMUST00000177303 ENSMUSP00000135131
ENSMUST00000177418
ENSMUST00000176879 ENSMUSP00000134766
ENSMUST00000176301
ENSMUST00000176316 ENSMUSP00000135808
ENSMUST00000176272
ENSMUST00000176539 ENSMUSP00000135612
ENSMUST00000176307 ENSMUSP00000134843
ENSMUST00000175911 ENSMUSP00000135428
ENSMUST00000175745 ENSMUSP00000135044
ENSMUST00000176226
ENSMUST00000176123
ENSMUST00000176514
ENSMUST00000177023 ENSMUSP00000134859
ENSMUST00000175779 ENSMUSP00000135177
ENSMUST00000176500 ENSMUSP00000134834
ENSMUST00000176400
ENSMUST00000176401
ENSMUST00000176243 ENSMUSP00000135771
ENSMUST00000177091
ENSMUST00000175749
ENSMUST00000175903 ENSMUSP00000135168
ENSMUST00000176079
ENSMUST00000176528
ENSMUST00000177120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017048 Rho GTPase binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000902 cell morphogenesis
GO:0007015 actin filament organization
GO:0007026 negative regulation of microtubule depolymerization
GO:0007067 mitotic nuclear division
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071225 cellular response to muramyl dipeptide
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005923 tight junction
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116584
View Gene Order
ENSBTAG00000000113
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
reelinpathway
Reelin signaling pathway
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.239329 Mm.474712
RefSeq NM_001198911 NM_001198912 NM_001198913 NM_008487 XM_006501058 XM_006501059 XM_006501060 XM_006501061 XM_006501062 XM_006501063 XM_006501064 XM_006501065 XM_006501066 XM_006501067
OMIM
CCDS CCDS17481 CCDS57220 CCDS57221 CCDS57222
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca