InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v1a

Summary

InnateDB Gene

IDBG-161436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1a

Gene Name

ATPase, H+ transporting, lysosomal V1 subunit A

Synonyms

AI647066; Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052459

Encoded Proteins

IDBP-161438

ATPase, H+ transporting, lysosomal V1 subunit A

IDBP-251279

ATPase, H+ transporting, lysosomal V1 subunit A

IDBP-539385

ATPase, H+ transporting, lysosomal V1 subunit A

IDBP-537949

ATPase, H+ transporting, lysosomal V1 subunit A

IDBP-537216

ATPase, H+ transporting, lysosomal V1 subunit A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114573:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:44085402-44139705

Strand

Reverse strand

Band

Transcripts

ENSMUST00000063661	ENSMUSP00000066886
ENSMUST00000114666	ENSMUSP00000110314
ENSMUST00000130036
ENSMUST00000137557	ENSMUSP00000116923
ENSMUST00000124102	ENSMUSP00000118429
ENSMUST00000147025	ENSMUSP00000118726

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0016324	apical plasma membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome