InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ophn1

Summary

InnateDB Gene

IDBG-161472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ophn1

Gene Name

oligophrenin 1

Synonyms

C130037N19Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031214

Encoded Proteins

IDBP-161474

oligophrenin 1

IDBP-253064

oligophrenin 1

IDBP-535234

oligophrenin 1

IDBP-539089

oligophrenin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079482:
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:98554277-98891025

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033560	ENSMUSP00000033560
ENSMUST00000113826	ENSMUSP00000109457
ENSMUST00000147529	ENSMUSP00000121723
ENSMUST00000154920
ENSMUST00000125150
ENSMUST00000147805
ENSMUST00000142267	ENSMUSP00000119361
ENSMUST00000156917
ENSMUST00000140598
ENSMUST00000156634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0030036	actin cytoskeleton organization
GO:0030100	regulation of endocytosis
GO:0032321	positive regulation of Rho GTPase activity
GO:0048488	synaptic vesicle endocytosis
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:1901799	negative regulation of proteasomal protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043195	terminal bouton
GO:0043197	dendritic spine

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000079482

View Gene Order

Pathways

NETPATH

REACTOME

REACT_206918

Signaling by Rho GTPases pathway

REACT_210090

Rho GTPase cycle pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.254336 Mm.33536 Mm.350624

RefSeq

NM_052976

OMIM

CCDS

CCDS30295

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas