Version 5.4
Mus musculus Gene: Csnk1e
Summary
InnateDB Gene IDBG-161704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csnk1e
Gene Name casein kinase 1, epsilon
Synonyms AI426939; AI551861; AW457082; CK1epsilon; CKIe; KC1epsilon; tau
Species Mus musculus
Ensembl Gene ENSMUSG00000022433
Encoded Proteins
IDBP-401262
casein kinase 1, epsilon
IDBP-401261
casein kinase 1, epsilon
IDBP-401263
casein kinase 1, epsilon
IDBP-532550
casein kinase 1, epsilon
IDBP-541881
casein kinase 1, epsilon
IDBP-534548
casein kinase 1, epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:79417856-79443919
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000117786 ENSMUSP00000113341
ENSMUST00000120859 ENSMUSP00000113975
ENSMUST00000122044 ENSMUSP00000113096
ENSMUST00000127155
ENSMUST00000145740
ENSMUST00000156513
ENSMUST00000137028
ENSMUST00000136003
ENSMUST00000144790 ENSMUSP00000115637
ENSMUST00000135519 ENSMUSP00000122135
ENSMUST00000156043 ENSMUSP00000116593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007623 circadian rhythm
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032922 circadian regulation of gene expression
GO:0034613 cellular protein localization
GO:0042752 regulation of circadian rhythm
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000213923
View Gene Order
Pathways
NETPATH
REACTOME
REACT_24972
Circadian Clock pathway
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_240530
G2/M Transition pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_241925
Circadian Clock pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_188804
Cell Cycle pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_188257
Signal Transduction pathway
REACT_225118
WNT mediated activation of DVL pathway
REACT_253753
Centrosome maturation pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu04310
Wnt signaling pathway pathway
mmu04340
Hedgehog signaling pathway pathway
mmu04710
Circadian rhythm pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_24941
Circadian Clock pathway
REACT_200668
WNT mediated activation of DVL pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa04710
Circadian rhythm pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30199 Mm.473156 Mm.487357
RefSeq NM_001289898 NM_001289899 NM_013767 XM_006521044 XM_006521046 XM_006521047
OMIM
CCDS CCDS27640 CCDS70646
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca