Version 5.4
Homo sapiens Gene: IFITM5
Summary
InnateDB Gene IDBG-16179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFITM5
Gene Name interferon induced transmembrane protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000206013
Encoded Proteins
IDBP-16181
interferon induced transmembrane protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:298200-299526
Strand Reverse strand
Band p15.5
Transcripts
ENST00000382614 ENSP00000372059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009607 response to biotic stimulus
GO:0030282 bone mineralization
GO:0030500 regulation of bone mineralization
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025489
View Gene Order
ENSBTAG00000020575
Not yet available
Cross-References
SwissProt A6NNB3
TrEMBL
UniProt Splice Variant
Entrez Gene 387733
UniGene Hs.443469
RefSeq NM_001025295
HUGO HGNC:16644
OMIM 614757
CCDS CCDS31323
HPRD
IMGT
EMBL BC150562 BC150563 CH471278
GenPept AAI50563 AAI50564 EAW61222
RNA Seq Atlas 387733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca