InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dap3

Summary

InnateDB Gene

IDBG-162225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dap3

Gene Name

death associated protein 3

Synonyms

4921514D13Rik; DAP-3; MRP-S29; S29mt

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068921

Encoded Proteins

IDBP-162227

death associated protein 3

IDBP-266554

death associated protein 3

IDBP-620818

death associated protein 3

IDBP-620819

death associated protein 3

IDBP-620821

death associated protein 3

IDBP-620822

death associated protein 3

IDBP-620823

death associated protein 3

IDBP-620825

death associated protein 3

IDBP-620828

death associated protein 3

IDBP-620829

death associated protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132676:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:88920803-88951181

Strand

Reverse strand

Band

Transcripts

ENSMUST00000090938	ENSMUSP00000088456
ENSMUST00000107491	ENSMUSP00000103115
ENSMUST00000173711
ENSMUST00000174571	ENSMUSP00000133349
ENSMUST00000173094	ENSMUSP00000133486
ENSMUST00000173135	ENSMUSP00000134422
ENSMUST00000174077	ENSMUSP00000134433
ENSMUST00000173021	ENSMUSP00000133314
ENSMUST00000174402	ENSMUSP00000133395
ENSMUST00000172942	ENSMUSP00000134145
ENSMUST00000174491	ENSMUSP00000134165
ENSMUST00000172790
ENSMUST00000188259

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008637

apoptotic mitochondrial changes

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005761	mitochondrial ribosome
GO:0015935	small ribosomal subunit