InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Qdpr

Summary

InnateDB Gene

IDBG-162283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Qdpr

Gene Name

quinoid dihydropteridine reductase

Synonyms

2610008L04Rik; D5Ertd371e; Dhpr; PKU2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015806

Encoded Proteins

IDBP-162285

quinoid dihydropteridine reductase

IDBP-401004

quinoid dihydropteridine reductase

IDBP-401002

quinoid dihydropteridine reductase

IDBP-401003

quinoid dihydropteridine reductase

IDBP-533172

quinoid dihydropteridine reductase

IDBP-536954

quinoid dihydropteridine reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151552:
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:45434032-45450235

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015950	ENSMUSP00000015950
ENSMUST00000117425	ENSMUSP00000112469
ENSMUST00000118097	ENSMUSP00000113958
ENSMUST00000120867	ENSMUSP00000113203
ENSMUST00000149290
ENSMUST00000154962	ENSMUSP00000122081
ENSMUST00000127562	ENSMUSP00000115453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004155	6,7-dihydropteridine reductase activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0070402	NADPH binding
GO:0070404	NADH binding

Biological Process

GO:0001889	liver development
GO:0006559	L-phenylalanine catabolic process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0008152	metabolic process
GO:0010044	response to aluminum ion
GO:0010288	response to lead ion
GO:0033762	response to glucagon
GO:0035690	cellular response to drug
GO:0055114	oxidation-reduction process