InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gnaz

Summary

InnateDB Gene

IDBG-162323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnaz

Gene Name

guanine nucleotide binding protein, alpha z subunit

Synonyms

AI847979; Gz

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040009

Encoded Proteins

IDBP-162325

guanine nucleotide binding protein, alpha z subunit

IDBP-534826

guanine nucleotide binding protein, alpha z subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128266:
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:74967177-75016907

Strand

Forward strand

Band

Transcripts

ENSMUST00000037813	ENSMUSP00000036087
ENSMUST00000160421
ENSMUST00000159991	ENSMUSP00000124639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0043087	regulation of GTPase activity

Cellular Component

GO:0005829	cytosol
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome