Version 5.4
Mus musculus Gene: O3far1
Summary
InnateDB Gene IDBG-162636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol O3far1
Gene Name omega-3 fatty acid receptor 1
Synonyms AI552415; Gpr120; Gpr129; GT01; KPG_013; O3far1; Pgr4
Species Mus musculus
Ensembl Gene ENSMUSG00000054200
Encoded Proteins
IDBP-162638
omega-3 fatty acid receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186188:
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38097079-38114263
Strand Forward strand
Band C2
Transcripts
ENSMUST00000067098 ENSMUSP00000063660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008527 taste receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010827 regulation of glucose transport
GO:0043066 negative regulation of apoptotic process
GO:0046879 hormone secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186188
View Gene Order
ENSBTAG00000000437
Not yet available
Pathways
NETPATH
REACTOME
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_231468
GPCR ligand binding pathway
REACT_198709
Free fatty acid receptors pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21268
Free fatty acid receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7TMA4
TrEMBL Q3V2S5
UniProt Splice Variant
Entrez Gene 107221
UniGene Mm.35288
RefSeq NM_181748
OMIM
CCDS CCDS29783
HPRD
IMGT
MGI ID MGI:2147577
MGI Symbol Ffar4
EMBL AB115769 AK131616 AY288424 BC053698 CH466534
GenPept AAH53698 AAP72133 BAD83369 BAE20722 EDL41800
RNA Seq Atlas 107221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca