Version 5.4
Mus musculus Gene: Clk2
Summary
InnateDB Gene IDBG-162830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clk2
Gene Name CDC-like kinase 2
Synonyms AU041688; Tu52
Species Mus musculus
Ensembl Gene ENSMUSG00000068917
Encoded Proteins
IDBP-162832
CDC-like kinase 2
IDBP-401109
CDC-like kinase 2
IDBP-401108
CDC-like kinase 2
IDBP-541273
CDC-like kinase 2
IDBP-541274
CDC-like kinase 2
IDBP-539694
CDC-like kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176444:
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89164795-89176921
Strand Forward strand
Band F1
Transcripts
ENSMUST00000090927 ENSMUSP00000088445
ENSMUST00000121212 ENSMUSP00000113390
ENSMUST00000121931 ENSMUSP00000113861
ENSMUST00000152205 ENSMUSP00000122202
ENSMUST00000138822
ENSMUST00000148265 ENSMUSP00000122634
ENSMUST00000128318 ENSMUSP00000115761
ENSMUST00000133323
ENSMUST00000153255
ENSMUST00000132830
ENSMUST00000139221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0010033 response to organic substance
GO:0010212 response to ionizing radiation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032526 response to retinoic acid
GO:0043484 regulation of RNA splicing
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176444
View Gene Order
ENSBTAG00000014393
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288098
RefSeq NM_001163432 NM_007712
OMIM
CCDS CCDS17491 CCDS50958
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca