Version 5.4
Mus musculus Gene: Pth2r
Summary
InnateDB Gene IDBG-162844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pth2r
Gene Name parathyroid hormone 2 receptor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025946
Encoded Proteins
IDBP-162846
parathyroid hormone 2 receptor
IDBP-531560
parathyroid hormone 2 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144407:
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:65282056-65389244
Strand Forward strand
Band C2
Transcripts
ENSMUST00000027083 ENSMUSP00000027083
ENSMUST00000140190 ENSMUSP00000114594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144407
View Gene Order
ENSBTAG00000011992
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YV95
UniProt Splice Variant
Entrez Gene 213527
UniGene Mm.294225
RefSeq NM_139270
OMIM
CCDS CCDS15017
HPRD
IMGT
MGI ID MGI:2180917
MGI Symbol Pth2r
EMBL AC164079 AC166985
GenPept
RNA Seq Atlas 213527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca