Version 5.4
Mus musculus Gene: Ggt5
Summary
InnateDB Gene IDBG-162988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ggt5
Gene Name gamma-glutamyltransferase 5
Synonyms AI551243; GGL; GGT-REL; Ggtla1
Species Mus musculus
Ensembl Gene ENSMUSG00000006344
Encoded Proteins
IDBP-162990
gamma-glutamyltransferase 5
IDBP-788995
gamma-glutamyltransferase 5
IDBP-788996
gamma-glutamyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099998:
This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn\'t convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75589340-75617200
Strand Forward strand
Band C1
Transcripts
ENSMUST00000072217 ENSMUSP00000072074
ENSMUST00000189972 ENSMUSP00000139459
ENSMUST00000189991 ENSMUSP00000141106
ENSMUST00000188444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006954 inflammatory response
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099998
View Gene Order
ENSBTAG00000006608
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188625
Arachidonic acid metabolism pathway
REACT_215561
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
KEGG
mmu00480
Glutathione metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00430
Taurine and hypotaurine metabolism pathway
mmu00460
Cyanoamino acid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23887
UniGene
RefSeq NM_011820
OMIM
CCDS CCDS23928
HPRD
IMGT
MGI ID MGI:1346063
MGI Symbol Ggt5
EMBL
GenPept
RNA Seq Atlas 23887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca