Version 5.4
Mus musculus Gene: Ttc8
Summary
InnateDB Gene IDBG-163183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttc8
Gene Name tetratricopeptide repeat domain 8
Synonyms 0610012F22Rik; AV001447; BBS8
Species Mus musculus
Ensembl Gene ENSMUSG00000021013
Encoded Proteins
IDBP-163185
tetratricopeptide repeat domain 8
IDBP-163187
tetratricopeptide repeat domain 8
IDBP-532833
tetratricopeptide repeat domain 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165533:
This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:98920574-98983238
Strand Forward strand
Band E
Transcripts
ENSMUST00000085109 ENSMUSP00000082190
ENSMUST00000079146 ENSMUSP00000078148
ENSMUST00000132878 ENSMUSP00000115828
ENSMUST00000124514
ENSMUST00000139298
ENSMUST00000168255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0005515 protein binding
Biological Process
GO:0007411 axon guidance
GO:0007608 sensory perception of smell
GO:0015031 protein transport
GO:0021772 olfactory bulb development
GO:0032880 regulation of protein localization
GO:0035058 nonmotile primary cilium assembly
GO:0035264 multicellular organism growth
GO:0042384 cilium assembly
GO:0045444 fat cell differentiation
GO:0048560 establishment of anatomical structure orientation
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0061326 renal tubule development
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005929 cilium
GO:0032391 photoreceptor connecting cilium
GO:0034464 BBSome
GO:0036064 ciliary basal body
GO:0060170 ciliary membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165533
View Gene Order
ENSBTAG00000030432
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.282660 Mm.410257
RefSeq NM_029553 NM_198311
OMIM
CCDS CCDS26101 CCDS26102
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca