Version 5.4
| Mus musculus Gene: Ptdss1 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-163188.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Ptdss1 | ||||||
| Gene Name | phosphatidylserine synthase 1 | ||||||
| Synonyms | AU044268; AW539008; mKIAA0024; PSS-1 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000021518 | ||||||
| Encoded Proteins |
phosphatidylserine synthase 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156471:
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).[supplied by OMIM, May 2009] The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 13:66932830-66998401 | ||||||
| Strand | Forward strand | ||||||
| Band | B3 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
Synthesis of PS pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
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| KEGG |
Glycerophospholipid metabolism pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Synthesis of PS pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Metabolism pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PS pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Phospholipid metabolism pathway
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| KEGG |
Glycerophospholipid metabolism pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | Q99LH2 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 19210 | ||||||
| UniGene | Mm.402676 | ||||||
| RefSeq | NM_008959 | ||||||
| OMIM | |||||||
| CCDS | CCDS26612 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:1276575 | ||||||
| MGI Symbol | Ptdss1 | ||||||
| EMBL | AF042731 AK036990 AK054101 AK085857 AK088048 AK137681 BC003260 | ||||||
| GenPept | AAB97845 AAH03260 BAC29660 BAC35656 BAC39555 BAC40117 BAE23459 | ||||||
| RNA Seq Atlas | 19210 | ||||||