Version 5.4
Mus musculus Gene: Ppargc1a
Summary
InnateDB Gene IDBG-163551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppargc1a
Gene Name peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms A830037N07Rik; ENSMUSG00000079510; Gm11133; PGC-1; Pgc-1alpha; PGC-1v; Pgc1; Pgco1; Ppargc1
Species Mus musculus
Ensembl Gene ENSMUSG00000029167
Encoded Proteins
IDBP-787628
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
IDBP-542637
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
IDBP-532831
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
IDBP-537007
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21966468
Ppargc1a is activated in Staphylococcus aureus-mediated sepsis via the Tlr2-signalling pathway.
InnateDB Annotation from Orthologs
Summary
PMID 21966468
[Homo sapiens] PPARGC1A is activated in Staphylococcus aureus-mediated sepsis via the TLR2-signalling pathway. (Demonstrated in mice)
PMID 25595716
[Homo sapiens] MIR130A reduces hepatitis B virus (HBV) replication by down-regulating the expression of two major metabolic regulators PPARGC1A and PPARG, both of which can potently stimulate HBV replication.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109819:
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:51454249-51567725
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000031059 ENSMUSP00000138397
ENSMUST00000132734 ENSMUSP00000117040
ENSMUST00000151104 ENSMUSP00000116566
ENSMUST00000127135 ENSMUSP00000115586
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 29 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001666 response to hypoxia
GO:0006012 galactose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007005 mitochondrion organization
GO:0008209 androgen metabolic process
GO:0009409 response to cold
GO:0010822 positive regulation of mitochondrion organization
GO:0010941 regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0014850 response to muscle activity
GO:0022904 respiratory electron transport chain
GO:0031325 positive regulation of cellular metabolic process
GO:0031667 response to nutrient levels
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0036273 response to statin
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0043201 response to leucine
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046321 positive regulation of fatty acid oxidation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051552 flavone metabolic process
GO:0070997 neuron death
GO:0071250 cellular response to nitrite
GO:0071356 cellular response to tumor necrosis factor
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0097067 cellular response to thyroid hormone stimulus
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:2000272 negative regulation of receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000507 positive regulation of energy homeostasis
GO:2001171 positive regulation of ATP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109819
View Gene Order
ENSBTAG00000017024
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_200794
Mus musculus biological processes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_205688
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
KEGG
mmu04910
Insulin signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_212213
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_224346
REV-ERBA represses gene expression pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_215625
RORA activates circadian gene expression pathway
REACT_210271
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_220844
Developmental Biology pathway
REACT_227144
Circadian Clock pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
atf2_pathway
ATF-2 transcription factor network
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL Q3LIG2
UniProt Splice Variant
Entrez Gene 19017
UniGene
RefSeq NM_008904 XM_006503774 XM_006503775 XM_006503776 XM_006503777 XM_006503778
OMIM
CCDS CCDS19282
HPRD
IMGT
MGI ID MGI:1342774
MGI Symbol Ppargc1a
EMBL AB061324 AC116763
GenPept BAE46507
RNA Seq Atlas 19017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca