InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: St13

Summary

InnateDB Gene

IDBG-164664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

St13

Gene Name

suppression of tumorigenicity 13

Synonyms

1110007I03Rik; 3110002K08Rik; AW555194; HIP; HOP; HSPABP; HSPABP1; p48; PRO0786; SNC6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022403

Encoded Proteins

IDBP-164666

suppression of tumorigenicity 13

IDBP-621864

suppression of tumorigenicity 13

IDBP-621866

suppression of tumorigenicity 13

IDBP-621867

suppression of tumorigenicity 13

IDBP-621868

suppression of tumorigenicity 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100380:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:81363669-81400077

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023039	ENSMUSP00000023039
ENSMUST00000172107	ENSMUSP00000130195
ENSMUST00000165582	ENSMUSP00000129966
ENSMUST00000163382	ENSMUSP00000131502
ENSMUST00000169204	ENSMUSP00000130525

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030544	Hsp70 protein binding
GO:0032403	protein complex binding
GO:0032564	dATP binding
GO:0042802	identical protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0051260	protein homooligomerization
GO:0061084	negative regulation of protein refolding
GO:0070389	chaperone cofactor-dependent protein refolding

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100380

View Gene Order

ENSBTAG00000006202

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q99L47

TrEMBL

E9Q1V0 E9Q1X9 Q3TGW8

UniProt Splice Variant

Entrez Gene

70356

UniGene

Mm.392737 Mm.416619 Mm.488628

RefSeq

NM_133726 XM_006521391 XM_006521392

OMIM

CCDS

CCDS27667

HPRD

IMGT

MGI ID

MGI:1917606

MGI Symbol

St13

EMBL

AC109153 AK146528 AK147169 AK159149 AK168557 BC003843 CT010318

GenPept

AAH03843 BAE27237 BAE27733 BAE34856 BAE40430 CAJ18526

RNA Seq Atlas

70356